5-Amino-1MQ
Research-grade 5-Amino-1MQ. COA included. Ships in 24-48hrs.
Chemical Properties
Verified compound data sourced directly from PubChem's scientific database
Product Description
5-Amino-1MQ is a research-grade small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), synthesized for controlled laboratory investigation. NNMT is a cytosolic enzyme that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as the methyl donor, producing 1-methylnicotinamide (1-MNA) as a byproduct. This enzymatic activity exerts broad influence over NAD⁺ bioavailability, methyl group metabolism, and the activity of downstream methylation-dependent processes including histone modification and gene expression regulation.
By selectively inhibiting NNMT, 5-Amino-1MQ is studied as a tool to probe the relationship between NAD⁺ metabolism, cellular energy flux, and metabolic phenotype. Research applications include investigation of adipocyte differentiation and lipid storage dynamics, mitochondrial biogenesis, insulin sensitivity, and the regulation of the SAM/SAH methylation ratio. Its ability to modulate both epigenetic and metabolic pathways positions it as a useful compound in multidisciplinary research spanning cell biology, metabolic disease, and aging science.
Available in 50mg vials, independently tested and supplied with a Certificate of Analysis (COA) confirming identity, purity, and concentration.
For research use only. Not intended for human or veterinary use.
